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Paul Bresge has been a leader in the cell and gene therapy biotech space for over a decade. He is co-founder and Chief Executive Officer at Ray Therapeutics, an optogenetics gene therapy company for blinding diseases. Prior to co-founding Ray Therapeutics, Paul served as Chief Executive Officer at jCyte, a late-stage clinical cell therapy company developing a treatment for retinitis pigmentosa. He was involved with jCyte prior to its inception in 2012 and concluded a $252M licensing deal with Santen Pharmaceutical in 2020. In addition to his current role as CEO, Paul is on the board of directors of Healios, an iPSC company with programs in ophthalmology and oncology, and is a mentor on the Winning Pitch Challenge. Paul is passionate about supporting companies with emerging technologies that have great potential to address unmet needs for patients with blinding and other diseases.
Chris Whitmore is a highly accomplished executive who brings over 20 years of strategic finance, accounting, and operational expertise. His deep experience spans from early-stage biotech to publicly-traded companies, with a focus on both private and public capital raising. He most recently served as CFO at Immune-Onc where he was instrumental in supporting the company’s progress into later-stage clinical trials, fundraising and executing strategic collaborations with Roche and Beigene. His leadership experience also includes management positions at Harpoon Therapeutics and Immune Design (both acquired by Merck), Notable Labs, AcelRx Pharmaceuticals, and Sangamo Therapeutics. Mr. Whitmore started his career at KPMG LLP, where he served as a manager in the audit practice. He received his B.A. in Business Economics from the University of California, Santa Barbara and holds an active CPA license.
Peter Francis is a highly experienced biotechnology executive and an ophthalmologist clinician-scientist with expertise in ophthalmic genetics and retinal disease. He graduated from medical school in the U.K. and undertook residency in London. He obtained his PhD in ophthalmic genetics from University College, London and is fellowship trained in Retina. Peter has almost two decades of experience in the biotechnology and pharmaceutical industries where he has led a number of gene therapy products from discovery to early-stage clinical development. Most recently he served as Chief Scientific Officer at 4D Molecular Therapeutics, a leader in AAV-based gene therapy and was prior, their first Chief Medical Officer and Head of Translational Research. Previously, Peter was Chief Medical Officer at RetroSense Therapeutics, the first visual optogenetics company which was successfully sold to a large pharmaceutical company. Peter is a member of the Macula Society, the American Ophthalmological Society and the American Academy of Ophthalmology. He has held academic faculty positions at St. Thomas’ Hospital, London and Casey Eye Institute, OHSU, Portland, OR. He has published about 100 peer-reviewed articles.
Jenny Holt, PMP is an experienced biotech and pharmaceutical executive with more than 25 years of experience primarily in gene therapies, ophthalmology, and oncolytic viral research. She is a graduate of UC Santa Barbara. Her first roles included scientist positions at UCSF Gladstone Institutes, Onyx Pharmaceuticals, and Novartis Institute of Biomedical Research. Most recently Jenny was head of project management at 4D Molecular Therapeutics, a leading AAV-based gene therapy company, where she managed five gene therapy products from discovery to early-stage clinical development. Jenny also was a co-founder/advisor at Ignite Immunotherapy which was purchased by Pfizer in 2019.
Jonathan Melnick has over 15 years of experience in the biotechnology industry, with a focus on platform development in the fields of high throughput biology and gene therapy. He received his bachelor’s degree from Cornell University in Chemistry and Biology, and his PhD in 2006 from The Scripps Research Institute. Jon specializes in a multidisciplinary approach to platform refinement and optimization, combining the principles of chemical biology with next generation sequencing (NGS) and bioinformatics/machine learning. Jon’s career has focused on early stage biotechs, where he has established teams and brought in new capabilities to expand academic platforms into industrial discovery engines.
Jerrod is a seasoned CMC leader in cell and gene therapy with over 2 decades of biotech experience. His first jobs were at 3 cell therapy therapeutic product development companies- Geron, ViaCyte and StemCells where he had increasing roles of responsibility in R&D, process and analytical development, pilot plant, GMP manufacturing and MSAT. He was then hired by Dark Horse Consulting Group as the first full-time employee and first Principal where he gained CMC experience in multiple types of cell therapies, ex vivo gene therapies and in vivo gene therapies including AAV products. After working at DHC, Jerrod took on a new challenge at Ology/National Resilience as VP of Cell Therapy Tech Ops for a CDMO. Most recently, Jerrod was VP of Cell Therapy Tech Ops at Athenex where we went back full circle to therapeutic product development of CAR-NKT cell therapy products.
Dr. Raj Agrawal is an Ophthalmologist and Retina Specialist with over 25 years of experience in clinical work, research and academia across four countries around the world, including India, Hong Kong, Bahamas and the US. Currently Vice President for Clinical Development and Therapeutic Area Lead at Ray Therapeutics, he was previously with Rezolute Inc, as VP of Clinical Development and Ophthalmology lead, heading the clinical development for an oral medication for diabetic macular edema; with Coherus Biosciences as Senior Vice President, Clinical Development and Ophthalmology lead where he led the clinical development of Cimerli™, a Lucentis biosimilar that was approved by the FDA in 2022; and with Santen Inc. as Senior Medical Director and Retina Lead where he led the retinal development program.
Dr. Agrawal was a full-time Clinical Faculty at Doheny Eye Institute and USC Keck School of Medicine, where, apart from clinical work and teaching fellows and residents, he was significantly involved in research, including being the co-patent holder for and involved in clinical trials and approval for ARGUS-II, the first-ever treatment for advanced retinitis pigmentosa in the world.
Dr. Agrawal is also the President and CEO of Retina Global, an international nonprofit that provides sustainable solutions to retinal disease management around the world. He is also the Founder of the Orange County Eye Project Eye Clinic in Santa Ana, CA.
VP & Head of Clinical Operations, Science & Quality
Vicki has over 30 years of clinical development operations experience in the biopharmaceutical industry. She has made significant contributions at companies ranging from biotech start-ups to large pharmaceutical companies, including contract research organizations. Working in small biotechs has allowed her to excel in clinical operations, data management and statistical programming. Therapeutic experience includes ocular diseases, neurodegenerative impairment, non-abusive pain therapy alternatives, and oncology. She is a graduate of Lehigh University.
Sean Ainsworth is a serial entrepreneur with multiple successes in starting, leading, and selling biotechnology companies. Previously, he founded and led RetroSense Therapeutics, an optogenetic gene therapy company that advanced into human clinical trials and sold to Allergan in 2016. Earlier, he was deeply involved in the launch of Compendia Bioscience, Inc., which was acquired by Life Technologies in 2012. Sean is currently CEO and Chairman of Immusoft, a cell therapy company dedicated developing B cells as biofactories for sustained delivery of therapeutic proteins in rare pediatric indications.
Raymond Camahort, Ph.D., is Partner at Novo Holdings Venture Investments. He has over 15 years of combined investment, business, and research experience, with expertise in biochemistry, genetics, and gene therapy/editing. Prior to joining Novo Ventures, Ray worked in business development at the Harvard University Office of Technology Development where his role was to facilitate commercialization of technologies developed in the chemistry and stem cell/regenerative biology departments. Ray has served on the Board of Directors of numerous companies, including Arcellx, Inspirna, iECURE, and Riva Therapeutics. He completed a National Institute of Health post-doctoral training fellowship at Harvard University and was a pre-doctoral fellow at the Stowers Institute for Medical Research in Kansas City, Missouri. He holds a Ph.D. from the University of Kansas in biochemistry and molecular biology and a B.S. in biological sciences from the University of California Santa Barbara.
Dmitry ‘Dima’ Kuzmin MSc (Oxon) PhD MRSB MIoD is the co-founder and managing partner of 4BIO Capital, a London-based investment firm focused on advanced therapies and a pioneer of advanced therapies investments. Before founding 4BIO, he served in several academic roles with research interests spanning structural biology and rational design of ion channels, optogenetics, gene therapy of neurological and psychiatric diseases, brain-computer interfaces, and information processing in the brain. He serves or served in the past on several company boards, including Araris Biotech, Redpin Therapeutics, RetroSense Therapeutics (acquired by Allergan), and others.
Hannah H. Chang is a Managing Director at Platanus, a global evergreen investment fund. Dr. Chang leads the firm’s healthcare venture capital strategy, investing in innovative biotechnology companies with transformative therapeutic potential. Representative investments include Korro Bio, Semma Therapeutics (acquired by Vertex Pharmaceuticals), Akouos (NASDAQ: AKUS, acquired by Eli Lilly), Inipharm, and Nuvig Therapeutics. She was previously an investment professional at 5AM Ventures where she helped found IDEAYA Biosciences (NASDAQ: IDYA) and served as a Board Observer for Crinetics Pharmaceuticals (NASDAQ: CRNX), among others. Earlier in her career Dr. Chang was a Project Leader at The Boston Consulting and a member of the Healthcare Practice in their Boston office. Dr. Chang obtained her M.D. from the Harvard-MIT Program in Health Sciences and Technology, Ph.D. in Biophysics from Harvard University, and B.A. in Chemistry from Princeton University. Her research has been published in Nature, Lancet, and Physical Review Letters. Dr. Chang trained clinically in internal medicine and ophthalmology at the Beth Israel Deaconess Medical Center and Massachusetts Eye and Ear Infirmary, respectively. She is a licensed physician in the District of Columbia.
Tiba Aynechi is a biotech investor with 20+ years of research and investment experience. Based in the Norwest San Francisco office, she invests in healthcare with a focus on early to mid-stage companies within the therapeutics sector. Prior to joining Norwest, Tiba spent over ten years at Novo Holdings A/S, one of the top life sciences investment firms, with offices in the US and Europe. In her previous role, she was responsible for the deployment of ~280M of capital in private biotech, MedTech and HCIT companies. Earlier in her career Tiba was a banker focused on M&A, licensing, and financing transactions involving biotech/pharma. Tiba attended the University of California Irvine where she received a Bachelor of Science degree in Physics with a Biomedical concentration. She also holds a Ph.D. in Biophysics from the University of California San Francisco, where she also did her Postdoctoral Fellowship. Tiba is also a published author of scientific articles and book chapters in rational drug design.
Gary Abrams, MD is an ophthalmologist and retina specialist and is professor and former chair of the Department of Ophthalmology at Wayne State University (WSU). He founded the Ligon Research Center of Vision, dedicated to restoring vision in the blind, at WSU in 2000. Dr. Abrams is former President of the Association for Research in Vision and Ophthalmology (ARVO) and has received many honors including the 2005 Paul Kayser International Award in Retina Research from the Schepens International Society and the 2015 Pyron Award in Retina Research from the American Society of Retina Specialists.
Brian Chow, Ph.D., is a Principal on the Therapeutics team and joined the Firm in 2022. Prior to Deerfield, Dr. Chow spent 10 years at the University of Pennsylvania, most recently as an Associate Professor of Bioengineering. Before that, he was the Head of Research Operations and Alliances for Sage Therapeutics and a Venture Associate at Third Rock Ventures. Dr. Chow holds a B.S. in Chemistry from Stanford University and a Ph.D. in Media Arts and Sciences from the Massachusetts Institute of Technology.